Inhibitors of trypsin-like serine proteases prevent DNA damage-induced neuronal death by acting upstream of the mitochondrial checkpoint and of p53 induction

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.

LA Greene, Arthur S. Tischler · Proceedings of the National Academy of Sciences · 1976 · 5.6K citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

Jamil Momand, Gerard P. Zambetti, David C. Olson et al. · Cell · 1992 · 3.1K citations

Medicine, Molecular Biology, Oncology +10

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

Cell · 1993 · 2.5K citations · Full text

Life Sciences, Genetics, Molecular Biology +10

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

Keisuke Kuida, Timothy S. Zheng, Songqing Na et al. · Nature · 1996 · 1.9K citations

Life Sciences, Neurobiology, Neuroscience +14

Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B

Alison J. Darmon, Donald W. Nicholson, R. Chris Bleackley · Nature · 1995 · 723 citations

Life Sciences, Immunology, Molecular Biology +14