NADPH Oxidase Subunit 4-Mediated Reactive Oxygen Species Contribute to Cycling Hypoxia-Promoted Tumor Progression in Glioblastoma Multiforme

Chia‐Hung Hsieh, Woei‐Cherng Shyu, Chien-Yi Chiang, Jung-Wen Kuo, Wu‐Chung Shen, Ren-Shyan Liu

PLoS ONE · 2011 · 107 citations · 23 references

DOIFull text

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Abstract

Cycling hypoxia-induced ROS via Nox4 is a critical aspect of cancer biology to consider for therapeutic targeting of cycling hypoxia-promoted HIF-1 activation and tumor progression in GBM.

References

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