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Frozen State Storage Instability of a Monoclonal Antibody: Aggregation as a Consequence of Trehalose Crystallization and Protein Unfolding

Protein ChemistryBiomolecular CondensatesProtein AssemblyProtein FoldingNatural SciencesMolecular BiologyProtein MisfoldingTrehalose CrystallizationProtein Phase SeparationMonoclonal AntibodyProtein RefoldingMedicineProtein UnfoldingBiophysicsStructural Biology