Concepedia

Protein Unfolding

Protein Unfolding is a biophysical process in which a protein loses its native three-dimensional structure, resulting in the disruption of secondary, tertiary, and quaternary interactions and leading to a transition from a functional, folded conformation to a non-functional, disordered state.

1.9K

Publications

114.7K

Citations

6.2K

Authors

1.5K

Institutions

Publications per year

2017–2026

295

Parents

Publications

1.9K

The stabilization of proteins by sucrose.

James Lee, Serge N. Timasheff · Journal of Biological Chemistry · 1981 · 1.1K citations · Full text

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Mechanical and chemical unfolding of a single protein: A comparison

Mariano Carrión‐Vázquez, Andrés F. Oberhauser, Susan A. Fowler et al. · Proceedings of the National Academy of Sciences · 1999 · 1K citations

, , +17

Protein Folding Intermediates: Native-State Hydrogen Exchange

Yawen Bai, Tobin R. Sosnick, Leland Mayne et al. · Science · 1995 · 999 citations

, , +17

Using circular dichroism collected as a function of temperature to determine the thermodynamics of protein unfolding and binding interactions

Norma J. Greenfield · Nature Protocols · 2006 · 902 citations · Full text

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Mechanical unfolding intermediates in titin modules

Piotr E. Marszałek, Hui Lü, Hongbin Li et al. · Nature · 1999 · 808 citations

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1–5 of 1.9K

Authors

6.2K

  1. JB
    Jayant B. Udgaonkar

    National Centre for Biological Sciences, India

    24 publications · 807 citations

    18

    h-index

  2. VD
    Valerie Daggett

    University of Washington, United States

    19 publications · 1.7K citations

    18

    h-index

  3. RL
    Robert L. Baldwin

    Stanford University, United States

    16 publications · 1.7K citations

    16

    h-index

  4. GI
    George I. Makhatadze

    Rensselaer Polytechnic Institute, United States

    15 publications · 2.4K citations

    15

    h-index

  5. RT
    Robert T. Sauer

    Massachusetts Institute of Technology, United States

    14 publications · 1.3K citations

    13

    h-index

1–5 of 6.2K

Institutions

1.5K

  1. Centre National de la Recherche Scientifique

    Paris, France

    26 h-index

    147 publications

    6.6K citations

  2. Johns Hopkins University

    Baltimore, United States

    26 h-index

    82 publications

    8.5K citations

  3. Massachusetts Institute of Technology

    Cambridge, United States

    25 h-index

    87 publications

    11.7K citations

  4. Stanford University

    Stanford, United States

    24 h-index

    65 publications

    7.4K citations

  5. National Institutes of Health

    Bethesda, United States

    23 h-index

    69 publications

    9.1K citations

  6. University of Washington

    Seattle, United States

    23 h-index

    60 publications

    5.6K citations

  7. University of Cambridge

    Cambridge, United Kingdom

    23 h-index

    99 publications

    15.6K citations

  8. Howard Hughes Medical Institute

    Chevy Chase, United States

    22 h-index

    59 publications

    8.5K citations

1–8 of 1.5K

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 103 publications · 13.3K citations

    66

    h-index

  2. Biochemistry

    248 publications · 12.7K citations

    57

    h-index

  3. Journal of Biological Chemistry

    JBC · 128 publications · 9.5K citations

    53

    h-index

  4. Journal of Molecular Biology

    JMB · 64 publications · 6.7K citations

    45

    h-index

  5. Journal of the American Chemical Society

    JACS · 51 publications · 4.9K citations

    36

    h-index

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