Novel off-target effect of tamoxifen — Inhibition of acid ceramidase activity in cancer cells

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

E. G. Bligh, W. J. Dyer · Canadian Journal of Biochemistry and Physiology · 1959 · 48.9K citations

Life Sciences, Biochemistry, Zoology +9

Hsp70 stabilizes lysosomes and reverts Niemann–Pick disease-associated lysosomal pathology

Thomas Kirkegaard, Anke G. Roth, Nikolaj H.T. Petersen et al. · Nature · 2010 · 521 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +10

Induction of apoptotic cell death and prevention of tumor growth by ceramide analogues in metastatic human colon cancer.

Markus Selzner, Alicja Bielawska, Michael Morse et al. · PubMed · 2001 · 339 citations

Medicine, Oncology, Pharmacology +17

Agents that Reverse Multidrug Resistance, Tamoxifen, Verapamil, and Cyclosporin A, Block Glycosphingolipid Metabolism by Inhibiting Ceramide Glycosylation in Human Cancer Cells

Yaakov Lavie, Hui-ting Cao, Alon Volner et al. · Journal of Biological Chemistry · 1997 · 286 citations · Full text

Medicine, Oncology, Pharmacology +17

The presence of sphingomyelin- and ceramide-cleaving enzymes in the small intestinal tract

Åke Nilsson · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · 1969 · 208 citations

Life Sciences, Biochemistry, Physiology +13