Concepedia

Off-target Effect Assessment

Off-Target Effect Assessment is a chemogenomic profiling method that identifies unintended interactions between bioactive compounds and non-intended molecular targets to evaluate the specificity and potential toxicity of therapeutic agents.

108

Publications

6.6K

Citations

797

Authors

336

Institutions

Publications per year

2017–2026

55

Parents

Publications

108

Pitfalls of the MTT assay: Direct and off-target effects of inhibitors can result in over/underestimation of cell viability

Aleksei A. Stepanenko, V. V. Dmitrenko · Gene · 2015 · 306 citations

, , +8

Identifying off-target effects and hidden phenotypes of drugs in human cells

Marnie L. MacDonald, Jane E. Lamerdin, Stephen Owens et al. · Nature Chemical Biology · 2006 · 297 citations

, , +16

siDirect 2.0: updated software for designing functional siRNA with reduced seed-dependent off-target effect

Yuki Naito, Jun Yoshimura, Shinichi Morishita et al. · BMC Bioinformatics · 2009 · 287 citations · Full text

, , +15

An Efficient Genotyping Method for Genome-modified Animals and Human Cells Generated with CRISPR/Cas9 System

Xiaoxiao Zhu, Yajie Xu, Shanshan Yu et al. · Scientific Reports · 2014 · 267 citations · Full text

, , +15

The Neisseria meningitidis CRISPR-Cas9 System Enables Specific Genome Editing in Mammalian Cells

Ciaran M. Lee, Thomas J. Cradick, Gang Bao · Molecular Therapy · 2016 · 250 citations · Full text

, , +16

1–5 of 108

Authors

797

  1. WL
    Wei Li

    Dana-Farber Cancer Institute, United States

    3 publications · 137 citations

    3

    h-index

  2. KU
    Kumiko Ui‐Tei

    The University of Tokyo, Japan

    3 publications · 533 citations

    3

    h-index

  3. LC
    Lumen Chao

    George Washington University, United States

    2 publications · 71 citations

    2

    h-index

  4. YN
    Yuki Naito

    The University of Tokyo, Japan

    2 publications · 467 citations

    2

    h-index

  5. XC
    Xiaolong Cheng

    Children's National, United States

    2 publications · 71 citations

    2

    h-index

1–5 of 797

Institutions

336

  1. Chinese Academy of Sciences

    Beijing, China

    5 h-index

    45 publications

    5.1K citations

  2. The University of Tokyo

    Tokyo, Japan

    4 h-index

    12 publications

    2.4K citations

  3. Merck & Co., Inc., Rahway, NJ, USA (United States)

    Rahway, United States

    3 h-index

    15 publications

    461 citations

  4. University of Chinese Academy of Sciences

    Beijing, China

    3 h-index

    20 publications

    892 citations

  5. The University of Melbourne

    Melbourne, Australia

    3 h-index

    19 publications

    558 citations

  6. Instituto de Salud Carlos III

    Madrid, Spain

    2 h-index

    5 publications

    97 citations

  7. National Institutes of Health

    Bethesda, United States

    2 h-index

    6 publications

    418 citations

  8. University of Toronto

    Toronto, Canada

    2 h-index

    14 publications

    658 citations

1–8 of 336

Venues

  1. Scientific Reports

    10 publications · 909 citations

    10

    h-index

  2. Journal of Chemical Information and Modeling

    JCIM · 4 publications · 247 citations

    4

    h-index

  3. Nature Communications

    4 publications · 173 citations

    4

    h-index

  4. Nucleic Acids Research

    4 publications · 454 citations

    4

    h-index

  5. Bioinformatics

    3 publications · 152 citations

    3

    h-index

1–5