Acid ceramidase is upregulated in AML and represents a novel therapeutic target

Su‐Fern Tan, Xin Liu, Todd E. Fox, +22

Oncotarget

Targeting of survivin by nanoliposomal ceramide induces complete remission in a rat model of NK-LGL leukemia

Xin Liu, Lindsay Ryland, Jun Yang, +19

Blood

Novel off-target effect of tamoxifen — Inhibition of acid ceramidase activity in cancer cells

Samy A.F. Morad, Jonathan C. Levin, Su‐Fern Tan, +3

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

Breast OncologyMedicineCancer Cell BiologyCancer BiologyBreast Cancer +7

Genomic landscape of TCRαβ and TCRγδ T-large granular lymphocyte leukemia

HeeJin Cheon, Jeffrey C. Xing, Katharine B. Moosic, +13

Blood

Acid ceramidase promotes drug resistance in acute myeloid leukemia through NF-κB-dependent P-glycoprotein upregulation

Su‐Fern Tan, Wendy Dunton, Xin Liu, +12

Journal of Lipid Research

Hematological MalignancyTumor BiologyAcid CeramidaseOncologyMedicine +11

Therapeutic efficacy of FTY720 in a rat model of NK-cell leukemia

Aijun Liao, Kathleen Broeg, Todd E. Fox, +21

Blood

Chemotherapy selection pressure alters sphingolipid composition and mitochondrial bioenergetics in resistant HL-60 cells

Li-Pin Kao, Samy A.F. Morad, Traci S. Davis, +14

Journal of Lipid Research

Targeting glucosylceramide synthase synergizes with C₆-ceramide nanoliposomes to induce apoptosis in natural killer cell leukemia

Rebecca Watters, Todd E. Fox, Su‐Fern Tan, +8

Leukemia & lymphoma/Leukemia and lymphoma

Ceramide-tamoxifen regimen targets bioenergetic elements in acute myelogenous leukemia

Samy A.F. Morad, Terence E. Ryan, P. Darrell Neufer, +12

Journal of Lipid Research

Vitamin D decreases STAT phosphorylation and inflammatory cytokine output in T-LGL leukemia

Kristine C. Olson, Paige M. Kulling, Thomas L. Olson, +4

Cancer Biology & Therapy

ImmunologyImmune RegulationCell DeathT-lgl LeukemiaStat Phosphorylation +22