Concepedia

Off-target Effect Analysis

Off-Target Effect Analysis is a systematic methodological framework in CRISPR-based engineering that identifies and quantifies unintended genomic modifications occurring at sites distinct from the target locus to assess the specificity and safety of gene-editing interventions.

191

Publications

20.8K

Citations

1.4K

Authors

484

Institutions

Publications per year

2017–2026

129

Parents

Publications

191

GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases

Shengdar Q. Tsai, Zongli Zheng, Nathalie T. Nguyen et al. · Nature Biotechnology · 2014 · 2.3K citations · Full text

, , +14

Evaluation of off-target and on-target scoring algorithms and integration into the guide RNA selection tool CRISPOR

Maximilian Haeussler, Kai Schönig, Hélène Eckert et al. · Genome biology · 2016 · 1.9K citations · Full text

, , +14

Digenome-seq: genome-wide profiling of CRISPR-Cas9 off-target effects in human cells

Daesik Kim, Sangsu Bae, Jeongbin Park et al. · Nature Methods · 2015 · 1K citations

, , +15

Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials

Ann Lin, Christopher J. Giuliano, Ann Palladino et al. · Science Translational Medicine · 2019 · 776 citations · Full text

, , +6

Multigeneration analysis reveals the inheritance, specificity, and patterns of CRISPR/Cas-induced gene modifications in <i>Arabidopsis</i>

Zhengyan Feng, Yanfei Mao, Nanfei Xu et al. · Proceedings of the National Academy of Sciences · 2014 · 667 citations · Full text

, , +17

1–5 of 191

Authors

1.4K

  1. JK
    J. Keith Joung

    Massachusetts General Hospital, United States

    5 publications · 2.7K citations

    5

    h-index

  2. JK
    Jin‐Soo Kim

    Seoul National University, South Korea

    6 publications · 2.4K citations

    5

    h-index

  3. DK
    Daesik Kim

    Seoul National University, South Korea

    5 publications · 1.4K citations

    5

    h-index

  4. EZ
    Erwei Zuo

    Chinese Academy of Agricultural Sciences, China

    4 publications · 161 citations

    4

    h-index

  5. JG
    John G. Doench

    Broad Institute, United States

    4 publications · 622 citations

    4

    h-index

1–5 of 1.4K

Institutions

484

  1. Harvard University

    Cambridge, United States

    13 h-index

    70 publications

    20.9K citations

  2. Chinese Academy of Sciences

    Beijing, China

    11 h-index

    88 publications

    15.5K citations

  3. Broad Institute

    Cambridge, United States

    10 h-index

    52 publications

    6.7K citations

  4. Stanford University

    Stanford, United States

    8 h-index

    58 publications

    10.4K citations

  5. University of Chinese Academy of Sciences

    Beijing, China

    8 h-index

    28 publications

    4K citations

  6. Massachusetts General Hospital

    Boston, United States

    8 h-index

    56 publications

    32.6K citations

  7. Howard Hughes Medical Institute

    Chevy Chase, United States

    6 h-index

    13 publications

    1.3K citations

  8. Center for Cancer Research

    Bethesda, United States

    6 h-index

    45 publications

    29.7K citations

1–8 of 484

Venues

  1. Nature Communications

    19 publications · 1.7K citations

    17

    h-index

  2. Scientific Reports

    12 publications · 1.3K citations

    11

    h-index

  3. Nucleic Acids Research

    11 publications · 1.8K citations

    11

    h-index

  4. bioRxiv (Cold Spring Harbor Laboratory)

    Repository · 9 publications · 180 citations

    9

    h-index

  5. Bioinformatics

    7 publications · 565 citations

    7

    h-index

1–5