Concepedia

Use of a folding model and in situ spectroscopic techniques for rational formulation development and stability testing of monoclonal antibody therapeutics**Gauri Rao and Vandana Iyer contributed equally to this work.

Gauri G. Rao, Vandana Iyer, Matthew P. Kosloski, Dipak S. Pisal, Eun‐kyoung Shin, C. Russell Middaugh, Sathy V. Balu‐Iyer

Journal of Pharmaceutical Sciences · 2009 · 13 citations · 11 references

Open access

Concepts

Folding ModelMonoclonal Antibody TherapeuticsProtein FoldingMedicineBioanalysisAntibody ScreeningDrug Delivery SystemsImmunochemistryAntibody EngineeringStability TestingPharmacologyBiophysicsBiomolecular Engineering

References

11

Evidence for a molten globule state as a general intermediate in protein folding

Oleg B. Ptitsyn, Roger H. Pain, Gennady V. Semisotnov et al. · FEBS Letters · 1990 · 677 citations

Protein Chemistry, Transient Intermediate, Bovine Carbonic Anhydrase +15

The Thermal Stability of Immunoglobulin: Unfolding and Aggregation of a Multi-Domain Protein

Arnoldus W. P. Vermeer, Willem Norde · Biophysical Journal · 2000 · 661 citations · Full text

Protein Chemistry, Multi-domain Protein, Protein Assembly +8

Overlooking Subvisible Particles in Therapeutic Protein Products: Gaps That May Compromise Product Quality

John F. Carpenter, Theodore W. Randolph, Wim Jiskoot et al. · Journal of Pharmaceutical Sciences · 2008 · 578 citations · Full text

Protein Chemistry, Biochemistry, Subvisible Particles +10

Differential scanning calorimetry of the irreversible thermal denaturation of thermolysin

José M. Sánchez‐Ruiz, José Luis López‐Lacomba, Manuel Cortijo et al. · Biochemistry · 1988 · 446 citations

Contribution of Variable Domains to the Stability of Humanized IgG1 Monoclonal Antibodies

Roxana Ionescu, Josef Vlasak, Colleen Price et al. · Journal of Pharmaceutical Sciences · 2007 · 315 citations

Autoimmune Disease, Immunology, Immunodominance +13