Concepedia

Prediction of Pharmacokinetics Prior to In Vivo Studies. II. Generic Physiologically Based Pharmacokinetic Models of Drug Disposition

Patrick Poulin, Frank‐Peter Theil

Journal of Pharmaceutical Sciences · 2002 · 300 citations · 20 references

DOI

Concepts

References

20

Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes

R. Scott Obach · Drug Metabolism and Disposition · 1999 · 1.2K citations

, , +17

Prediction of Pharmacokinetics Prior to In Vivo Studies. 1. Mechanism‐Based Prediction of Volume of Distribution

Patrick Poulin, Frank‐Peter Theil · Journal of Pharmaceutical Sciences · 2002 · 560 citations

, , +14

A Priori Prediction of Tissue:Plasma Partition Coefficients of Drugs to Facilitate the Use of Physiologically‐Based Pharmacokinetic Models in Drug Discovery

Patrick Poulin, Frank‐Peter Theil · Journal of Pharmaceutical Sciences · 2000 · 423 citations

, , +8

Prediction of adipose tissue: Plasma partition coefficients for structurally unrelated drugs

Patrick Poulin, Kerstin Schoenlein, Frank‐Peter Theil · Journal of Pharmaceutical Sciences · 2001 · 210 citations

, , +9

In vitro andin vivo evaluation of the tissue-to-blood partition coefficient for physiological pharmacokinetic models

Jiunn H. Lin, Yuichi Sugiyama, Shoji Awazu et al. · Journal of Pharmacokinetics and Biopharmaceutics · 1982 · 148 citations

, , +12