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Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance

Signal TransductionSignal 2T-regulatory CellImmunologyCell DeathSignal 1AutoimmunityPeripheral Allograft ToleranceImmunomodulationTolerance InductionCell BiologyImmunotherapyMedicineCell TransplantationCell SignalingGraft Rejection