Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance

Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways

Christian P. Larsen, Eric T. Elwood, Diane Z. Alexander et al. · Nature · 1996 · 1.5K citations

Life Sciences, Cardiology, Immunology +16

CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-xL

Lawrence Boise, Andy J. Minn, Patricia J. Noel et al. · Immunity · 1995 · 1.2K citations · Full text

Life Sciences, Cell Biology, Immunology +13

Long-Term Survival of Xenogeneic Pancreatic Islet Grafts Induced by CTLA4lg

Deborah J. Lenschow, Yijun Zeng, J. Richard Thistlethwaite et al. · Science · 1992 · 1.1K citations

Life Sciences, Endocrinology, Immunology +17

CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates

Allan D. Kirk, David M. Harlan, Nicholas Armstrong et al. · Proceedings of the National Academy of Sciences · 1997 · 933 citations

Life Sciences, Immunology, Pharmacology +17

Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates

Allan D. Kirk, Linda C. Burkly, D. Scott Batty et al. · Nature Medicine · 1999 · 827 citations

Life Sciences, Immunology, Nephrology +14