Decahydroquinoline amides as highly selective CB2 agonists: Role of selectivity on in vivo efficacy in a rodent model of analgesia

Allodynia and Hyperalgesia in Adjuvant-Induced Arthritic Rats: Time Course of Progression and Efficacy of Analgesics

Yukinori Nagakura, Masamichí Okada, Atsuyuki Kohara et al. · Journal of Pharmacology and Experimental Therapeutics · 2003 · 179 citations

Medicine, Pharmacology, Pain Management +12

Evaluation of Cerebrospinal Fluid Concentration and Plasma Free Concentration As a Surrogate Measurement for Brain Free Concentration

Xingrong Liu, Bill J. Smith, Cuiping Chen et al. · Drug Metabolism and Disposition · 2006 · 161 citations

Pharmacy, Pharmacokinetics, Pharmacology +17

<i>In vitro</i>and<i>in vivo</i>characterization of A‐796260: a selective cannabinoid CB₂receptor agonist exhibiting analgesic activity in rodent pain models

B. B. Yao, Gin C. Hsieh, Jennifer M. Frost et al. · British Journal of Pharmacology · 2007 · 136 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Discovery of 2-[(2,4-Dichlorophenyl)amino]- <i>N</i> -[(tetrahydro- 2 <i>H</i> -pyran-4-yl)methyl]-4-(trifluoromethyl)- 5-pyrimidinecarboxamide, a Selective CB2 Receptor Agonist for the Treatment of Inflammatory Pain

Gerard M.P. Giblin, Celestine T. O’Shaughnessy, Alan Naylor et al. · Journal of Medicinal Chemistry · 2007 · 120 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Anhydrous cerium(III) chloride — Effect of the drying process on activity and efficiency

Kalina Kostova, Miroslav Genov · Tetrahedron Letters · 1996 · 100 citations

Natural Sciences, Chemical Engineering, Chemistry +9