Nature Genetics · 1997 · 227 citations · 23 references
MedicineCancer BiologyOncologyApoptosisCarcinogenesisRadiobiologyApoptosis In CancerCellular Radiation ResponseRadiation CarcinogenesisRadiation TherapyRadiation ToxicityRadiation-induced Cell DeathApoptosis After IrradiationIonizing Radiation CarcinogenesisP53 InactivationP53 MutationRadiation-induced Apoptosis
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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
Lawrence A. Donehower, Michele Harvey, Betty L. Slagle et al. · Nature · 1992 · 4.7K citations
Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms
David Malkin, Frederick P. Li, Louise C. Strong et al. · Science · 1990 · 3.8K citations
Life Sciences, Genetics, Oncology +17
p53-dependent apoptosis modulates the cytotoxicity of anticancer agents
Scott W. Lowe, H. Earl Ruley, Tyler Jacks et al. · Cell · 1993 · 2.9K citations
p53 is required for radiation-induced apoptosis in mouse thymocytes
Scott W. Lowe, Earlene M. Schmitt, Sallie W. Smith et al. · Nature · 1993 · 2.9K citations
Medicine, Cell Biology, Oncology +14