Concepedia

Signal peptide peptidase dependent cleavage of type II transmembrane substrates releases intracellular and extracellular signals

Kumlesh K. Dev, Sandipan Chatterjee, Maribel Osinde, Daniela Stauffer, Hannah L. Morgan, Monika Kobialko, Uwe Dengler, Heinrich Rueeger, Bruno Martoglio, Giorgio Rovelli

European Journal of Pharmacology · 2006 · 29 citations · 24 references

DOI

Concepts

References

24

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity

Michael S. Wolfe, Weiming Xia, Beth L. Ostaszewski et al. · Nature · 1999 · 1.9K citations

, , +8

Crucial Step in Cholesterol Homeostasis

Tong Yang, Peter J. Espenshade, Michael E. Wright et al. · Cell · 2002 · 984 citations · Full text

, , +14

Drosophila Rhomboid-1 Defines a Family of Putative Intramembrane Serine Proteases

Siniša Urban, Jeffrey R. Lee, Matthew Freeman · Cell · 2001 · 568 citations · Full text

, , +9

Sterol-Regulated Release of SREBP-2 from Cell Membranes Requires Two Sequential Cleavages, One Within a Transmembrane Segment

Juro Sakai, Elizabeth A. Duncan, Robert B. Rawson et al. · Cell · 1996 · 530 citations · Full text

, , +9

Identification of Signal Peptide Peptidase, a Presenilin-Type Aspartic Protease

Andreas Weihofen, Kathleen L. Binns, Marius K. Lemberg et al. · Science · 2002 · 529 citations

, , +16