Concepedia

Design, synthesis and SAR of potent statine-based BACE-1 inhibitors: Exploration of P1 phenoxy and benzyloxy residues

Marcus Bäck, Jonas Nyhlén, Ingemar Kvarnström, Sara Appelgren, Neera Borkakoti, Katarina Jansson, Jimmy Lindberg, Susanne Nyström, Anders Hallberg, Åsa Rosenquist,

Bioorganic & Medicinal Chemistry · 2008 · 30 citations · 22 references

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22

Mice deficient in BACE1, the Alzheimer's β-secretase, have normal phenotype and abolished β-amyloid generation

Yi Luo, Brad Bolon, Steve Kahn et al. · Nature Neuroscience · 2001 · 994 citations

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BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

Steven L. Roberds · Human Molecular Genetics · 2001 · 703 citations

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Control of Peripheral Nerve Myelination by the ß-Secretase BACE1

Michael Willem, Alistair N. Garratt, Božidar Novak et al. · Science · 2006 · 686 citations

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Structure-Based Design of Potent and Selective Cell-Permeable Inhibitors of Human β-Secretase (BACE-1)

Shawn J. Stachel, Craig A. Coburn, Thomas G. Steele et al. · Journal of Medicinal Chemistry · 2004 · 277 citations · Full text

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Crystal structures of native and inhibited forms of human cathepsin D: implications for lysosomal targeting and drug design.

Eric T. Baldwin, Talapady N. Bhat, Sergei Gulnik et al. · Proceedings of the National Academy of Sciences · 1993 · 274 citations

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