Indoleamine 2,3-dioxygenase-expressing dendritic cells are involved in the generation of CD4+CD25+regulatory T cells in Peyer's patches in an orally tolerized, collagen-induced arthritis mouse model

Abstract

Our data suggest that tolerogenic CD11c+ DCs are closely linked with the induction of oral tolerance through an IDO-dependent mechanism and that this pathway may provide a new therapeutic modality to treat autoimmune arthritis.