Synthesis of pyrazolo 3,4-pyrimidine analogues of the potent agent N-4-2-2-amino-4 3-oxo-7-pyrrolo 2,3-pyrimidin-5-yl ethylbenzoyl-L-glutamic acid (LY231514)

Potential Purine Antagonists. I. Synthesis of Some 4,6-Substituted Pyrazolo [3,4-d] pyrimidines¹

Roland K. Robins · Journal of the American Chemical Society · 1956 · 244 citations

Pharmaceutical Science, Potential Purine Antagonists, Bioorganic Chemistry +16

A potent antitumour quinazoline inhibitor of thymidylate synthetase: Synthesis, biological properties and therapeutic results in mice

Terence R. Jones, A H Calvert, Ann L. Jackman et al. · European Journal of Cancer (1965) · 1981 · 239 citations

Antiparasitic Agent, Medicine, Molecular Biology +8

Quinazoline antifolate thymidylate synthase inhibitors: heterocyclic benzoyl ring modifications

Peter R. Marsham, Leslie R. Hughes, Ann L. Jackman et al. · Journal of Medicinal Chemistry · 1991 · 78 citations · Full text

Medicinal Chemistry, Bioorganic Chemistry, Heterocyclic +12

Quinazoline antifolate thymidylate synthase inhibitors: alkyl, substituted alkyl, and aryl substituents in the C-2 position

Leslie R. Hughes, Ann L. Jackman, J.W. Oldfield et al. · Journal of Medicinal Chemistry · 1990 · 73 citations · Full text

Convergent and efficient palladium-effected synthesis of 5, 10-dideaza-5,6,7,8-tetrahydrofolic acid (DDATHF)

Edward C. Taylor, George S. K. Wong · The Journal of Organic Chemistry · 1989 · 68 citations

Cross-coupling Reaction, Molecular Sciences, Engineering +15