Leslie R. Hughes

Stereoselective synthesis of (.+-.)-indolizidines 167B, 205A, and 207A. Enantioselective synthesis of (-)-indolizidine 209B

Andrew B. Holmes, Adrian L. Smith, Simon F. Williams et al. · The Journal of Organic Chemistry · 1991 · 112 citations

B. Holmes, Engineering, Natural Sciences +12

Quinazoline antifolate thymidylate synthase inhibitors: heterocyclic benzoyl ring modifications

Peter R. Marsham, Leslie R. Hughes, Ann L. Jackman et al. · Journal of Medicinal Chemistry · 1991 · 78 citations · Full text

Medicinal Chemistry, Bioorganic Chemistry, Heterocyclic +12

Quinazoline antifolate thymidylate synthase inhibitors: alkyl, substituted alkyl, and aryl substituents in the C-2 position

Leslie R. Hughes, Ann L. Jackman, J.W. Oldfield et al. · Journal of Medicinal Chemistry · 1990 · 73 citations · Full text

The biochemical pharmacology of the thymidylate synthase inhibitor, 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583)

Ann L. Jackman, David R. Newell, William Gibson et al. · Biochemical Pharmacology · 1991 · 59 citations

Molecular Pharmacology, Biochemical Pharmacology, Pharmaceutical Chemistry +10

Stereoselective synthesis of (.+-.)-indolizidines 167B, 205A, and 207A. Enantioselective synthesis of (-)-indolizidine 209B

Adrian L. Smith, Simon F. Williams, Andrew B. Holmes et al. · Journal of the American Chemical Society · 1988 · 58 citations

Engineering, Donut Icon, Natural Sciences +12