Concepedia

Determinants of changes in plasma homocysteine in hyperthyroidism and hypothyroidism

M. J. M. Diekman, Nathalie MJ van der Put, Henk J. Blom, Jan G.P. Tijssen, W M Wiersinga

Clinical Endocrinology · 2001 · 103 citations · 13 references

DOIFull text

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Abstract

Plasma tHCys concentrations increased in hypothyroidism and decreased in hyperthyroidism. Plasma fT(4) is an independent determinant of tHCys concentrations. Lower folate levels and a lower creatinine clearance in hypo-thyroidism, and a higher creatinine clearance in hyperthyroidism only partially explain the changes in tHCys.

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