High Commitment of Embryonic Keratinocytes to Terminal Differentiation through a Notch1-caspase 3 Regulatory Mechanism

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

Donald W. Nicholson, Ambereen Ali, Nancy A. Thornberry et al. · Nature · 1995 · 4K citations

Protein Function, Biochemistry, Ice/ced-3 Protease +11

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

Keisuke Kuida, Timothy S. Zheng, Songqing Na et al. · Nature · 1996 · 1.9K citations

Molecular Neuroscience, Apoptosis, Autophagy +12

Calcium regulation of growth and differentiation of mouse epidermal cells in culture

Henry Hennings, Delores Michael, Christina Cheng et al. · Cell · 1980 · 1.8K citations

Developmental Biology, Calcium Regulation, Morphogenesis +10

Signalling downstream of activated mammalian Notch

Sophie Jarriault, Christel Brou, Frédérique Logeat et al. · Nature · 1995 · 1.4K citations

Developmental Biology, Signal Transduction, Signaling Pathway +8

GSK-3α regulates production of Alzheimer's disease amyloid-β peptides

Christopher J. Phiel, Virginia M.‐Y. Lee, Peter S. Klein · Nature · 2003 · 1.2K citations

Neurodegenerative Diseases, Molecular Neuroscience, Alzheimer's Disease +7