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Pharmacokinetics of Amitriptyline and One of Its Metabolites, Nortriptyline, in Rats: Little Contribution of Considerable Hepatic First-Pass Effect to Low Bioavailability of Amitriptyline Due to Great Intestinal First-Pass Effect

Little ContributionHepatologyPharmacological StudyMedicineLiver PhysiologyPhysiologyHepatotoxicityPharmacotherapyAmitriptyline DuePharmacologyLow BioavailabilityHealth Sciences