Concepedia

Liver First-pass Effect

Liver First-Pass Effect is a pharmacokinetic phenomenon in which a drug's bioavailability is reduced due to its extensive metabolism in the liver following absorption from the gastrointestinal tract and prior to systemic circulation.

117

Publications

4.7K

Citations

484

Authors

160

Institutions

Publications per year

2017–2026

15

Parents

Publications

117

Evolution of the Health Benefits of Soy Isoflavones

Stephen Barnes · Experimental Biology and Medicine · 1998 · 250 citations

, , +9

Metabolism, oral bioavailability and pharmacokinetics of chemopreventive kaempferol in rats

Avantika Barve, Chi Chen, Vidya Hebbar et al. · Biopharmaceutics & Drug Disposition · 2009 · 187 citations

, , +17

First-pass effect of nalorphine in rats.

K Iwamoto, C D Klaassen · Journal of Pharmacology and Experimental Therapeutics · 1977 · 151 citations

, , +17

Metabolism of Garlic Constituents in the Isolated Perfused Rat Liver*

C. Egen-Schwind, F. H. Kemper · Planta Medica · 1992 · 145 citations

, , +14

Pharmacokinetic-Pharmacodynamic Analysis of the Glucose-Lowering Effect of Metformin in Diabetic Rats Reveals First-Pass Pharmacodynamic Effect

David Stepensky, Michael Friedman, Itamar Raz et al. · Drug Metabolism and Disposition · 2002 · 135 citations

, , +15

1–5 of 117

Authors

484

  1. MG
    Myung G. Lee

    Seoul National University, South Korea

    4 publications · 219 citations

    4

    h-index

  2. KS
    Kye S. Han

    Seoul National University, South Korea

    3 publications · 68 citations

    3

    h-index

  3. MG
    Myung Gull Lee

    Seoul National University, South Korea

    3 publications · 45 citations

    3

    h-index

  4. ZL
    Zhixiong Li

    Shanghai Institute of Materia Medica, China

    3 publications · 85 citations

    3

    h-index

  5. JW
    Jun Watanabe

    Tohoku University, Japan

    3 publications · 72 citations

    3

    h-index

1–5 of 484

Institutions

160

  1. Seoul National University

    Seoul, South Korea

    10 h-index

    27 publications

    991 citations

  2. Rutgers, The State University of New Jersey

    New Brunswick, United States

    4 h-index

    13 publications

    1.1K citations

  3. Shanghai Institute of Materia Medica

    Pudong, China

    3 h-index

    26 publications

    722 citations

  4. University of Toronto

    Toronto, Canada

    3 h-index

    8 publications

    196 citations

  5. University of Chinese Academy of Sciences

    Beijing, China

    3 h-index

    26 publications

    722 citations

  6. Nagoya City University

    Nagoya, Japan

    3 h-index

    10 publications

    233 citations

  7. Chinese Academy of Sciences

    Beijing, China

    3 h-index

    24 publications

    902 citations

  8. United States Military Academy

    West Point, United States

    2 h-index

    5 publications

    424 citations

1–8 of 160

Venues

  1. Drug Metabolism and Disposition

    11 publications · 448 citations

    10

    h-index

  2. PubMed

    Repository · 10 publications · 351 citations

    10

    h-index

  3. Journal of Pharmacy and Pharmacology

    JPP · 8 publications · 273 citations

    8

    h-index

  4. 6

    h-index

  5. Xenobiotica

    5 publications · 152 citations

    5

    h-index

1–5