Concepedia

Pharmacokinetic-Pharmacodynamic Analysis of the Glucose-Lowering Effect of Metformin in Diabetic Rats Reveals First-Pass Pharmacodynamic Effect

David Stepensky, Michael Friedman, Itamar Raz, Amnon Hoffman

Drug Metabolism and Disposition · 2002 · 133 citations · 18 references

DOI

References

18

Comparison of four basic models of indirect pharmacodynamic responses

Natalie Dayneka, Varun Garg, William J. Jusko · Journal of Pharmacokinetics and Biopharmaceutics · 1993 · 803 citations · Full text

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Metformin kinetics in healthy subjects and in patients with diabetes mellitus.

GT Tucker, Clare E. Casey, PJ Phillips et al. · British Journal of Clinical Pharmacology · 1981 · 490 citations · Full text

Accumulation of metformin by tissues of the normal and diabetic mouse

Carol Wilcock, Clifford J. Bailey · Xenobiotica · 1994 · 411 citations

Pharmacokinetics of metformin after intravenous and oral administration to man

P. J. Pentik�inen, Pertti J. Neuvonen, Aneri Penttil� · European Journal of Clinical Pharmacology · 1979 · 345 citations

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Disposition of metformin (N,N‐dimethylbiguanide) in man

Cesare R. Sirtori, Guido Franceschini, M. Galli-Kienle et al. · Clinical Pharmacology & Therapeutics · 1978 · 219 citations