Dose-Independent Pharmacokinetics of Metformin in Rats: Hepatic and Gastrointestinal First-Pass Effects

A physiological approach to hepatic drug clearance

G. Wilkinson, David G. Shand · Clinical Pharmacology & Therapeutics · 1975 · 1.9K citations

Pharmacy, Pharmacokinetics, Pharmacology +17

Critical evaluation of the potential error in pharmacokinetic studies of using the linear trapezoidal rule method for the calculation of the area under the plasma level-time curve

Win L. Chiou · Journal of Pharmacokinetics and Biopharmaceutics · 1978 · 623 citations

Pharmacy, Clinical Pharmacokinetics, Pharmacokinetics +14

Metformin kinetics in healthy subjects and in patients with diabetes mellitus.

GT Tucker, Clare E. Casey, PJ Phillips et al. · British Journal of Clinical Pharmacology · 1981 · 495 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +17

COMPARISON OF IN VITRO DRUG METABOLISM BY LUNG, LIVER, AND KIDNEY OF SEVERAL COMMON LABORATORY SPECIES

Charles L. Litterst, Edward G. Mimnaugh, Reginald L. Reagan et al. · Drug Metabolism and Disposition · 1975 · 270 citations

Medicine, Biochemistry, Pharmacology +15

Disposition of metformin (N,N‐dimethylbiguanide) in man

Cesare R. Sirtori, Guido Franceschini, M. Galli-Kienle et al. · Clinical Pharmacology & Therapeutics · 1978 · 220 citations

Pharmacy, Pharmacokinetics, Pharmacology +16