Food Effect and Biocomparison of Two Formulations of the Dual Orexin Receptor Antagonist Almorexant in Healthy Male Subjects

Promotion of sleep by targeting the orexin system in rats, dogs and humans

Catherine Brisbare‐Roch, Jasper Dingemanse, Ralf Koberstein et al. · Nature Medicine · 2007 · 567 citations

Life Sciences, Neurobiology, Neuroscience +12

Reduced parasympathetic cardiac control in patients with hypertension at rest and under mental stress

Wolf Langewitz, Heinz Rüddel, Hartmut Schächinger · American Heart Journal · 1994 · 167 citations

Medicine, Cardiology, Psychology +13

Orexin Receptor Antagonism, a New Sleep-Promoting Paradigm: An Ascending Single-Dose Study With Almorexant

Petra Hoever, SL de Haas, Julia Winkler et al. · Clinical Pharmacology & Therapeutics · 2010 · 101 citations

Medicine, Pharmacokinetics, Pharmacology +13

Cognitive and psychomotor function in hypoglycemia: response error patterns and retest reliability

Hartmut Schächinger · Pharmacology Biochemistry and Behavior · 2003 · 41 citations

Social Sciences, Behavioral Sciences, Psychology +16

Improved understanding of the effect of food on drug absorption and bioavailability for lipophilic compounds using an intestinal pig perfusion model

E.M. Persson, Anders Nordgren, Patrik Forsell et al. · European Journal of Pharmaceutical Sciences · 2008 · 27 citations

Pharmacy, Pharmacokinetics, Pharmacology +15