Dopamine covalently modifies and functionally inactivates parkin

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

Tohru Kitada, Shuichi Asakawa, Nobutaka Hattori et al. · Nature · 1998 · 5.2K citations

Life Sciences, Genetics, Molecular Genetics +10

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

Hideki Shimura, Nobutaka Hattori, Shinichiro Kubo et al. · Nature Genetics · 2000 · 2K citations

Life Sciences, Molecular Biology, Neuroscience +14

Kinetic Stabilization of the α-Synuclein Protofibril by a Dopamine-α-Synuclein Adduct

Kelly A. Conway, Jean‐Christophe Rochet, Robert M. Bieganski et al. · Science · 2001 · 1.1K citations

Life Sciences, Neurobiology, Neuroscience +17

The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization

Rosa Canet-Aviles, Mark A. Wilson, David W. Miller et al. · Proceedings of the National Academy of Sciences · 2004 · 1.1K citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

An Unfolded Putative Transmembrane Polypeptide, which Can Lead to Endoplasmic Reticulum Stress, Is a Substrate of Parkin

Yuzuru Imai, Mariko Soda, Haruhisa Inoue et al. · Cell · 2001 · 1.1K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +8