Unique autoreactive T cells recognize insulin peptides generated within the islets of Langerhans in autoimmune diabetes

The insulin gene is transcribed in the human thymus and transcription levels correlate with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes

Alberto Pugliese, Markus Zeller, Alarico Fernandez et al. · Nature Genetics · 1997 · 947 citations

Life Sciences, Genetics, Molecular Genetics +8

Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice

Maki Nakayama, Norio Abiru, Hiroaki Moriyama et al. · Nature · 2005 · 745 citations · Full text

Life Sciences, Endocrinology, Immunology +9

Low avidity recognition of self-antigen by T cells permits escape from central tolerance

George Y. Liu, Paul J. Fairchild, Richard Smith et al. · Immunity · 1995 · 414 citations · Full text

Life Sciences, Immunology, Adaptive Immunity +15

Initiation of Autoimmune Diabetes by Developmentally Regulated Presentation of Islet Cell Antigens in the Pancreatic Lymph Nodes

Petter Höglund, Justine D. Mintern, Caroline Waltzinger et al. · The Journal of Experimental Medicine · 1999 · 406 citations · Full text

Life Sciences, Endocrinology, Immunology +17

Epitope specificity, cytokine production profile and diabetogenic activity of insulin‐specific T cell clones isolated from NOD mice

Dylan Daniel, Ronald G. Gill, Nanette C. Schloot et al. · European Journal of Immunology · 1995 · 356 citations

Life Sciences, Endocrinology, Immunology +16