Inhibition of leukocyte-type 12-lipoxygenase by guava tea leaves prevents development of atherosclerosis

Disruption of the 12/15-lipoxygenase gene diminishes atherosclerosis in apo E–deficient mice

Tillmann Cyrus, Joseph L. Witztum, Daniel J. Rader et al. · Journal of Clinical Investigation · 1999 · 521 citations · Full text

Life Sciences, Immunology, Pathobiology +15

Colocalization of 15-lipoxygenase mRNA and protein with epitopes of oxidized low density lipoprotein in macrophage-rich areas of atherosclerotic lesions.

Seppo Ylä‐Herttuala, Margaret Rosenfeld, S Parthasarathy et al. · Proceedings of the National Academy of Sciences · 1990 · 428 citations

Life Sciences, Pathobiology, Pathology +15

Gene expression in macrophage-rich human atherosclerotic lesions. 15-lipoxygenase and acetyl low density lipoprotein receptor messenger RNA colocalize with oxidation specific lipid-protein adducts.

Seppo Ylä‐Herttuala, Michael E. Rosenfeld, Srinivasan Parthasarathy et al. · Journal of Clinical Investigation · 1991 · 380 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Inhibition of 15-lipoxygenases by flavonoids: structure–activity relations and mode of action

Christian D. Sadik, Helmut Sies, T Schewe · Biochemical Pharmacology · 2003 · 330 citations

Life Sciences, Medicinal Chemistry, Pharmacology +7

Macrophage-mediated 15-lipoxygenase expression protects against atherosclerosis development.

Junkang Shen, Edward E. Herderick, J. Fredrick Cornhill et al. · Journal of Clinical Investigation · 1996 · 233 citations · Full text

Life Sciences, Animal Sciences, Animal Nutrition +16