Synthesis, resolution, and absolute configuration of novel tricyclic benzodiazepines

5-Fluoro-2-methyl-<i>N</i>-[4-(5<i>H</i>-pyrrolo[2,1-<i>c</i>]- [1,4]benzodiazepin-10(11<i>H</i>)-ylcarbonyl)-3- chlorophenyl]benzamide (VPA-985):  An Orally Active Arginine Vasopressin Antagonist with Selectivity for V₂Receptors

J. Donald Albright, Marvin F. Reich, Efren G. Delos Santos et al. · Journal of Medicinal Chemistry · 1998 · 148 citations · Full text

Altmetric Attention Score, Pharmacotherapy, Experimental Pharmacology +16

NMR methods for determination of enantiomeric excess.

Robert Rothchild · PubMed · 2000 · 91 citations

Engineering, Magnetic Resonance, Molecular Biology +17

Orally Active, Nonpeptide Vasopressin V₂ Receptor Antagonists:  A Novel Series of 1-[4-(Benzoylamino)benzoyl]-2,3,4,5-tetrahydro-1<i>H</i>-benzazepines and Related Compounds

Hidenori Ogawa, Hiroshi Yamashita, Kazumi Kondo et al. · Journal of Medicinal Chemistry · 1996 · 84 citations · Full text

Terminal Benzoyl Ring, Molecular Pharmacology, Medicinal Chemistry +13

Highly Potent and Orally Active Non-Peptide Arginine Vasopressin Antagonists for Both V1A and V2 Receptors: Synthesis and Pharmacological Properties of 4'-[(4,4-Difluoro-5-methylidene-2,3,4,5-tetrahydro-1H-1-benzoazepin-1-yl)carbonyl]-2-phenylbenzanililde Derivatives.

Yoshiaki Shimada, K. Sakamoto, Takeyuki Yatsu et al. · Chemical and Pharmaceutical Bulletin · 2000 · 34 citations · Full text

Potent Affinity, Organic Chemistry, Pharmacotherapy +18

Synthesis of Opically Active 3-Morpholinecarboxylic Acid and Tetrahydro-2<i>H</i>-1,4-thiazine-3-carboxylic Acid

Yuji Kogami, Kenji Okawa · Bulletin of the Chemical Society of Japan · 1987 · 31 citations · Full text

Thio Analogue, Active 3-Morpholinecarboxylic Acid, Organic Chemistry +6