William J. Hoekstra

Structural analyses of Candida albicans sterol 14α-demethylase complexed with azole drugs address the molecular basis of azole-mediated inhibition of fungal sterol biosynthesis

Tatiana Y. Hargrove, Laura Friggeri, Z. Wawrzak et al. · Journal of Biological Chemistry · 2017 · 408 citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

Design, synthesis, and biological characterization of a peptide-mimetic antagonist for a tethered-ligand receptor

Patricia Andrade‐Gordon, Bruce E. Maryanoff, Claudia K. Derian et al. · Proceedings of the National Academy of Sciences · 1999 · 187 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

Design and optimization of highly-selective fungal CYP51 inhibitors

William J. Hoekstra, Edward P. Garvey, William R. Moore et al. · Bioorganic & Medicinal Chemistry Letters · 2014 · 181 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +11

Design and optimization of highly-selective, broad spectrum fungal CYP51 inhibitors

Christopher M. Yates, Edward P. Garvey, Sammy R. Shaver et al. · Bioorganic & Medicinal Chemistry Letters · 2017 · 82 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12

Discovery and Optimization of a Novel Series of Thrombin Receptor (PAR-1) Antagonists:  Potent, Selective Peptide Mimetics Based on Indole and Indazole Templates

Han‐Cheng Zhang, Claudia K. Derian, Patricia Andrade‐Gordon et al. · Journal of Medicinal Chemistry · 2001 · 75 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +10