Enhanced Intrapulmonary Delivery of Anticancer siRNA for Lung Cancer Therapy Using Cationic Ethylphosphocholine-based Nanolipoplexes

Rational design of cationic lipids for siRNA delivery

Sean C. Semple, Akin Akinc, Jianxin Chen et al. · Nature Biotechnology · 2010 · 1.7K citations

Lipid Preparation, Nanomedicine, Engineering +3

A combinatorial library of lipid-like materials for delivery of RNAi therapeutics

Akin Akinc, Andreas Zumbuehl, Michael S. Goldberg et al. · Nature Biotechnology · 2008 · 1.2K citations

Cell-based Drug Delivery, Nanomedicine, Lipid Preparation +9

A two-stage poly(ethylenimine)-mediated cytotoxicity: implications for gene transfer/therapy

S. Moein Moghimi, Peter Symonds, J. Clifford Murray et al. · Molecular Therapy · 2005 · 1.1K citations · Full text

Membrane Damage, Polymer-drug Conjugate, Medicine +14

Cationic lipid saturation influences intracellular delivery of encapsulated nucleic acids

James Heyes, Lorne Palmer, K. Helen Bremner et al. · Journal of Controlled Release · 2005 · 554 citations

Cell-based Drug Delivery, Biochemistry, Natural Sciences +4

Using siRNA in prophylactic and therapeutic regimens against SARS coronavirus in Rhesus macaque

Bao-jian Li, Qingquan Tang, Du Cheng et al. · Nature Medicine · 2005 · 439 citations · Full text

Therapeutic Regimens, Viral Persistence, Rhesus Macaque +9