Concepedia

Inhibitor of apoptosis signal-regulating kinase 1 protects against acetaminophen-induced liver injury

Yuchao Xie, Anup Ramachandran, David G. Breckenridge, John T. Liles, Margitta Lebofsky, Anwar Farhood, Hartmut Jaeschke

Toxicology and Applied Pharmacology · 2015 · 113 citations · 51 references

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51

Mammalian thioredoxin is a direct inhibitor of apoptosis signal‐regulating kinase (ASK) 1

Masao Saitoh · The EMBO Journal · 1998 · 2.4K citations · Full text

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Induction of Apoptosis by ASK1, a Mammalian MAPKKK That Activates SAPK/JNK and p38 Signaling Pathways

Hidenori Ichijo, Eisuke Nishida, Kenji Irie et al. · Science · 1997 · 2.3K citations

, , +16

The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation

Mitchell R. McGill, Matthew R. Sharpe, C. David Williams et al. · Journal of Clinical Investigation · 2012 · 763 citations · Full text

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ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity

Atsushi Matsuzawa, Kaoru Saegusa, Takuya Noguchi et al. · Nature Immunology · 2005 · 659 citations

, , +15

ASK1 Is Essential for JNK/SAPK Activation by TRAF2

Hideki Nishitoh, Masao Saitoh, Yoshiyuki Mochida et al. · Molecular Cell · 1998 · 652 citations · Full text

, , +10