Nonhematopoietic cells represent a more rational target of in vivo hedgehog signaling affecting normal or acute myeloid leukemia progenitors

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

Dominique Bonnet, John E. Dick · Nature Medicine · 1997 · 6.9K citations

Medicine, Hematology, Oncology +14

A cell initiating human acute myeloid leukaemia after transplantation into SCID mice

Tsvee Lapidot, Christian Sirard, Josef Vormoor et al. · Nature · 1994 · 4.7K citations

Medicine, Cell Biology, Hematology +14

Self-Renewing Osteoprogenitors in Bone Marrow Sinusoids Can Organize a Hematopoietic Microenvironment

Benedetto Sacchetti, Alessia Funari, Stefano Michienzi et al. · Cell · 2007 · 2.2K citations · Full text

Medicine, Cell Biology, Hematology +14

Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

Louis Vermeulen, Felipe de Sousa e Melo, Maartje van der Heijden et al. · Nature Cell Biology · 2010 · 1.8K citations

Life Sciences, Cancer Biology, Cell Biology +10

Multiple defects in innate and adaptive immunologic function in NOD/LtSz- <i>scid</i> mice.

Leonard D. Shultz, Peter A. Schweitzer, Sherri W. Christianson et al. · The Journal of Immunology · 1995 · 1.2K citations

Life Sciences, Immunology, Pathology +11