Acute myeloid leukaemia disrupts endogenous myelo-erythropoiesis by compromising the adipocyte bone marrow niche

Allison L. Boyd, Jennifer Reid, Kyle R. Salci, +16

Nature Cell Biology

Hematological MalignancyBone Marrow FailureMalignant Blood DisorderHematologyImmunology +6

Identification of Chemotherapy-Induced Leukemic-Regenerating Cells Reveals a Transient Vulnerability of Human AML Recurrence

Allison L. Boyd, Lili Aslostovar, Jennifer Reid, +8

Cancer Cell

Hematological MalignancyMedicineTransient VulnerabilityChemotherapy-induced Leukemic-regenerating CellsMixed-phenotype Acute Leukemia +7

Regional Localization within the Bone Marrow Influences the Functional Capacity of Human HSCs

Borhane Guezguez, Clinton J.V. Campbell, Allison L. Boyd, +7

Cell stem cell

Niche displacement of human leukemic stem cells uniquely allows their competitive replacement with healthy HSPCs

Allison L. Boyd, Clinton J.V. Campbell, Claudia I. Hopkins, +8

The Journal of Experimental Medicine

Sam68 Allows Selective Targeting of Human Cancer Stem Cells

Yannick D. Benoit, Ryan R. Mitchell, Ruth M. Risueño, +16

Cell chemical biology

Induced Pluripotent Stem CellMedicineStem Cell ResearchCancer BiologyCell Biology +1

A phase 1 trial evaluating thioridazine in combination with cytarabine in patients with acute myeloid leukemia

Lili Aslostovar, Allison L. Boyd, Mohammed Almakadi, +10

Blood Advances

CXCL12/CXCR4 Signaling Enhances Human PSC-Derived Hematopoietic Progenitor Function and Overcomes Early In Vivo Transplantation Failure

Jennifer Reid, Borko Tanasijevic, Diana Golubeva, +4

Stem Cell Reports

Nonhematopoietic cells represent a more rational target of in vivo hedgehog signaling affecting normal or acute myeloid leukemia progenitors

Allison L. Boyd, Kyle R. Salci, Zoya Shapovalova, +2

Experimental Hematology

Hematological MalignancyDevelopmental BiologyMixed-phenotype Acute LeukemiaVivo HedgehogRational Target +6

Phosphorylation state of the histone variant H2A.X controls human stem and progenitor cell fate decisions

Luca Orlando, Borko Tanasijevic, Mio Nakanishi, +10

Cell Reports

Targeting SUMOylation dependency in human cancer stem cells through a unique SAE2 motif revealed by chemical genomics

Yannick D. Benoit, Ryan R. Mitchell, Wenliang Wang, +24

Cell chemical biology

Molecular PathwayMedicineNatural SciencesMolecular BiologyUnique Sae2 Motif +7