Direct conversion of human fibroblasts to multilineage blood progenitors

Éva Szabó, Shravanti Rampalli, Ruth M. Risueño, +5

Nature

Regenerative MedicineDirect ConversionMedicineMatrix BiologyStem Cells +3

Single Transcription Factor Conversion of Human Blood Fate to NPCs with CNS and PNS Developmental Capacity

Jong‐Hee Lee, Ryan R. Mitchell, Jamie McNicol, +9

Cell Reports

Blood CellNeurochemical BiomarkersGliomaSocial SciencesNeuroregeneration +18

Activation of Neural Cell Fate Programs Toward Direct Conversion of Adult Human Fibroblasts into Tri-Potent Neural Progenitors Using <i>OCT-4</i>

Ryan R. Mitchell, Éva Szabó, Yannick D. Benoit, +7

Stem Cells and Development

Adult HumanStem Cell MigrationDirect Conversion ProcessStem Cell BiologyRegenerative Medicine +16

Sam68 Allows Selective Targeting of Human Cancer Stem Cells

Yannick D. Benoit, Ryan R. Mitchell, Ruth M. Risueño, +16

Cell chemical biology

Induced Pluripotent Stem CellMedicineStem Cell ResearchCancer BiologyCell Biology +1

Somatic transcriptome priming gates lineage-specific differentiation potential of human-induced pluripotent stem cell states

Jong‐Hee Lee, Jung Bok Lee, Zoya Shapovalova, +6

Nature Communications

Somatic TranscriptomeInduced Pluripotent Stem CellLineage PlasticityCell SpecializationMedicine +7

Lineage-Specific Differentiation Is Influenced by State of Human Pluripotency

Jong‐Hee Lee, Sarah Laronde, Tony Collins, +8

Cell Reports

Human Pluripotency Is Initiated and Preserved by a Unique Subset of Founder Cells

Mio Nakanishi, Ryan R. Mitchell, Yannick D. Benoit, +7

Cell

Human CellInduced Pluripotent Stem CellDevelopmental BiologyCell SpecializationFounder Cells +9

Molecular Evidence for OCT4-Induced Plasticity in Adult Human Fibroblasts Required for Direct Cell Fate Conversion to Lineage Specific Progenitors

Ryan R. Mitchell, Éva Szabó, Zoya Shapovalova, +3

Stem Cells

Oct4 Plasticity InductionCell DifferentiationIpsc FormationDirect ConversionMolecular Evidence +15

Phosphorylation state of the histone variant H2A.X controls human stem and progenitor cell fate decisions

Luca Orlando, Borko Tanasijevic, Mio Nakanishi, +10

Cell Reports

Targeting SUMOylation dependency in human cancer stem cells through a unique SAE2 motif revealed by chemical genomics

Yannick D. Benoit, Ryan R. Mitchell, Wenliang Wang, +24

Cell chemical biology

Molecular PathwayMedicineNatural SciencesMolecular BiologyUnique Sae2 Motif +7