Substrate specificity for rat cytochrome P450 (CYP) isoforms: screening with cDNA-expressed systems of the rat

Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines.

Marguerite A. Butler, M. Iwasaki, F. Peter Guengerich et al. · Proceedings of the National Academy of Sciences · 1989 · 638 citations · Full text

Metabolomic Profiling, Pharmacotherapy, Cytochrome P-450pa +16

Regulation of rat hepatic cytochrome P-450: age-dependent expression, hormonal imprinting, and xenobiotic inducibility of sex-specific isoenzymes

David J. Waxman, Ghazi A. Dannan, F. Peter Guengerich · Biochemistry · 1985 · 598 citations

Cytochrome P450 specificities of alkoxyresorufin O-dealkylation in human and rat liver

M.D. Burke, S. Thompson, Richard Weaver et al. · Biochemical Pharmacology · 1994 · 552 citations

Chemical Biology, Redox Biology, Oxidative Stress +16

Hydroxylation of chlorzoxazone as a specific probe for human liver cytochrome P-450IIE1

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Oxidation of midazolam and triazolam by human liver cytochrome P450IIIA4.

Thomas Kronbach, Daniel Mathys, Makoto Umeno et al. · Molecular Pharmacology · 1989 · 534 citations