The role of p53-induced apoptosis in cerebral ischemia: effects of the p53 inhibitor pifithrin ?

Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures.

Emanuela Bonfoco, Dimitri Krainc, Maria Ankarcrona et al. · Proceedings of the National Academy of Sciences · 1995 · 2K citations · Full text

Life Sciences, Neurobiology, Neuroscience +16

A Chemical Inhibitor of p53 That Protects Mice from the Side Effects of Cancer Therapy

Pavel G. Komarov, Elena A. Komarova, Roman V. Kondratov et al. · Science · 1999 · 1.3K citations

Medicine, Oncology, Pharmacology +17

Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective

Tong Cheng, Dong Liu, John H. Griffin et al. · Nature Medicine · 2003 · 559 citations

Life Sciences, Cell Biology, Neuroscience +16

Quantitative evaluation of blood-brain barrier permeability following middle cerebral artery occlusion in rats

Ludmila Belayev, Raul Busto, Weizhao Zhao et al. · Brain Research · 1996 · 505 citations · Full text

Medicine, Neurobiology, Neuroscience +17

Bax-Dependent Caspase-3 Activation Is a Key Determinant in p53-Induced Apoptosis in Neurons

Sean P. Cregan, Jason G. MacLaurin, Constance G. Craig et al. · Journal of Neuroscience · 1999 · 385 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17