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Emanuela Bonfoco, Dimitri Krainc, Maria Ankarcrona, +2

Proceedings of the National Academy of Sciences

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Gaucher Disease Glucocerebrosidase and α-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies

Joseph R. Mazzulli, You-Hai Xu, Ying Sun, +6

Cell

Neurodegenerative Diseasesα-Synuclein FormPathogenesisPathologyMolecular Biology +4

A call for transparent reporting to optimize the predictive value of preclinical research

Story C. Landis, Susan Amara, Khusru Asadullah, +33

Nature

Defects in Adaptive Energy Metabolism with CNS-Linked Hyperactivity in PGC-1α Null Mice

Jiandie D. Lin, Pei-Hsuan Wu, Paul T. Tarr, +20

Cell

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Transcriptional Repression of PGC-1α by Mutant Huntingtin Leads to Mitochondrial Dysfunction and Neurodegeneration

Libin Cui, Hyunkyung Jeong, Fran Borovečki, +3

Cell

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Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease

Lena F. Burbulla, Pingping Song, Joseph R. Mazzulli, +13

Science

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Yvette C. Wong, Daniel Ysselstein, Dimitri Krainc

Nature

Mitochondrial FunctionMitochondrial DynamicMedicineNatural SciencesMitochondrial Dynamics +5

Human iPSC-Based Modeling of Late-Onset Disease via Progerin-Induced Aging

Justine D. Miller, Yosif Ganat, Sarah Kishinevsky, +14

Cell stem cell

Human Ipsc-based ModelingAgingDisease ProgressionLongevityMedicine +3

Sp1 and TAFII130 Transcriptional Activity Disrupted in Early Huntington's Disease

Anthone W. Dunah, Hyunkyung Jeong, April M. Griffin, +7

Science

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Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1α in Huntington's disease neurodegeneration

Patrick Weydt, Victor V. Pineda, Anne E Torrence, +16

Cell Metabolism

Neurodegenerative DiseasesDisease NeurodegenerationGeneticsInherited Metabolic DiseaseDegenerative Disease +5