Treatment of Crohn’s disease with anti-IL-6 receptor antibody

Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: Evidence in Crohn disease and experimental colitis in vivo

Raja Atreya, Jonas Mudter, Susetta Finotto et al. · Nature Medicine · 2000 · 1.3K citations

Life Sciences, Immunology, Pathology +17

A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn’s disease☆

Hiroaki Ito, Masakazu Takazoe, Yoshihiro Fukuda et al. · Gastroenterology · 2004 · 639 citations · Full text

Veterinary Medicine, Immunology, Clinical Immunology +13

Cis3/Socs3/Ssi3 Plays a Negative Regulatory Role in Stat3 Activation and Intestinal Inflammation

Asuka Suzuki, Toshikatsu Hanada, Keiichi Mitsuyama et al. · The Journal of Experimental Medicine · 2001 · 477 citations · Full text

Life Sciences, Immunology, Pathology +17

IL-6 Is Required for the Development of Th1 Cell-Mediated Murine Colitis

Mitsunari Yamamoto, Kazuyuki Yoshizaki, Tadamitsu Kishimoto et al. · The Journal of Immunology · 2000 · 412 citations · Full text

Veterinary Medicine, Immunology, Pathology +17

Reshaping a human antibody to inhibit the interleukin 6-dependent tumor cell growth.

Koh Sato, Masayuki Tsuchiya, José W. Saldanha et al. · PubMed · 1993 · 277 citations

Pharmacy, Oncology, Pharmacology +17