A cell-based, multiparametric sensor approach characterises drug-induced cytotoxicity in human liver HepG2 cells

Intracellular Adenosine Triphosphate (ATP) Concentration: A Switch in the Decision Between Apoptosis and Necrosis

Marcel Leist, Barbara Single, Anna Federica Castoldi et al. · The Journal of Experimental Medicine · 1997 · 1.9K citations · Full text

Life Sciences, Biochemistry, Cell Biology +14

Expression of Thirty-six Drug Transporter Genes in Human Intestine, Liver, Kidney, and Organotypic Cell Lines

Constanze Hilgendorf, Gustav Ahlin, Annick Seithel et al. · Drug Metabolism and Disposition · 2007 · 580 citations

Medicine, Cell Biology, Pharmacology +14

Cytochrome P450 enzyme levels in HepG2 cells and cryopreserved primary human hepatocytes and their induction in HepG2 cells

Walter M.A. Westerink, W.G.E.J. Schoonen · Toxicology in Vitro · 2007 · 525 citations

Medicine, Biochemistry, Pharmacology +16

The toxicity of acetaminophen and N-acetyl-p-benzoquinone imine in isolated hepatocytes is associated with thiol depletion and increased cytosolic Ca2+.

Matthew D. Moore, Hjördis Thor, Gregory Moore et al. · Journal of Biological Chemistry · 1985 · 411 citations · Full text

Pharmacy, Pharmacology, Toxicology +17

The Biochemical and Cellular Basis of Cell Proliferation Assays That Use Tetrazolium Salts

Michael V. Berridge, An S. Tan, Kathy D. McCoy et al. · 1996 · 373 citations

Life Sciences, Biochemistry, Cell Biology +17