Concepedia

HCC cells with high levels of Bcl-2 are resistant to ABT-737 via activation of the ROS–JNK–autophagy pathway

Zhenhong Ni, Bin Wang, Xufang Dai, Wen Ding, Ting Yang, Xinzhe Li, Seth J. Lewin, Liang Xu, Jiqin Lian, Fengtian He

Free Radical Biology and Medicine · 2014 · 85 citations · 40 references

DOI

Concepts

References

40

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

The EMBO Journal · 2000 · 6.5K citations · Full text

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Bcl-2 Antiapoptotic Proteins Inhibit Beclin 1-Dependent Autophagy

Sophie Pattingre, Amina Tassa, Xueping Qu et al. · Cell · 2005 · 3.5K citations · Full text

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Bcl-2 functions in an antioxidant pathway to prevent apoptosis

David M. Hockenbery, Zoltán N. Oltvai, Xiao-Ming Yin et al. · Cell · 1993 · 3.4K citations

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JNK1-Mediated Phosphorylation of Bcl-2 Regulates Starvation-Induced Autophagy

Yongjie Wei, Sophie Pattingre, Sangita C. Sinha et al. · Molecular Cell · 2008 · 1.3K citations · Full text

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The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized

Mark F. van Delft, Andrew H. Wei, Kylie D. Mason et al. · Cancer Cell · 2006 · 1.2K citations · Full text

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