CYTOKINE PRODUCTION IN LINOMIDE-TREATED NOD MICE AND THE POTENTIAL ROLE OF A Th1/Th2 SHIFT ON AUTOIMMUNE AND ANTI-INFLAMMATORY PROCESSES

Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression.

René de Waal Malefyt, John B.A.G. Haanen, Hergen Spits et al. · The Journal of Experimental Medicine · 1991 · 1.9K citations · Full text

Life Sciences, Cell Biology, Immunology +15

IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells

David Fiorentino, Albert Zlotnik, Paulo Vieira et al. · The Journal of Immunology · 1991 · 1.9K citations · Full text

Life Sciences, Cell Biology, Immunology +12

T Helper Cell Subsets in Insulin-Dependent Diabetes

Jonathan D. Katz, Christophe Benoıst, Diane Mathis · Science · 1995 · 594 citations

Life Sciences, Endocrinology, Immunology +16

Recombinant Human IL-10 Prevents the Onset of Diabetes in the Nonobese Diabetic Mouse

Kenneth J. Pennline, Elizabeth Roque-Gaffney, Margaret Monahan · Clinical Immunology and Immunopathology · 1994 · 429 citations

Medicine, Endocrinology, Immunology +10

Interleukin 12 administration induces T helper type 1 cells and accelerates autoimmune diabetes in NOD mice.

Sylvie Trembleau, Giuseppe Penna, Emanuele Bosi et al. · The Journal of Experimental Medicine · 1995 · 422 citations · Full text

Life Sciences, Endocrinology, Immunology +17