Microarray Compound Screening (μARCS) to Identify Inhibitors of HIV Integrase

HIV-1 integrase inhibitors that compete with the target DNA substrate define a unique strand transfer conformation for integrase

Amy S. Espeseth, Peter J. Felock, Abigail Wolfe et al. · Proceedings of the National Academy of Sciences · 2000 · 318 citations · Full text

Life Sciences, Medicinal Chemistry, Molecular Biology +17

Differential inhibition of HIV-1 preintegration complexes and purified integrase protein by small molecules.

Chris M. Farnet, B Wang, J. Russell Lipford et al. · Proceedings of the National Academy of Sciences · 1996 · 121 citations

Life Sciences, Medicinal Chemistry, Molecular Biology +15

A novel assay for the DNA strand-transfer reaction of HIV-1 integrase

Daria J. Hazuda, Jeffrey C. Hastings, Abigail Wolfe et al. · Nucleic Acids Research · 1994 · 118 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +12

Calculating log P(oct) with no missing fragments;The problem of estimating new interaction parameters

Albert J. Leo, David Hoekman · Perspectives in Drug Discovery and Design · 2000 · 106 citations

Natural Sciences, Computer Science, Physics +6

Total Gene Synthesis: Novel Single-Step and Convergent Strategies Applied to the Construction of a 779 Base Pair Bacteriorhodopsin Gene

Guo-Qiang Chen, Isaac Choi, Banurekha Ramachandran et al. · Journal of the American Chemical Society · 1994 · 35 citations

Life Sciences, Biotechnology, Molecular Biology +6