Tim Middleton

NMR-Based Discovery of Lead Inhibitors That Block DNA Binding of the Human Papillomavirus E2 Protein

Philip J. Hajduk, Jürgen Dinges, Gregory F. Miknis et al. · Journal of Medicinal Chemistry · 1997 · 167 citations · Full text

Molecular Biology, Lead Identification, Chemical Biology +19

Activity of a Potent Hepatitis C Virus Polymerase Inhibitor in the Chimpanzee Model

Chih‐Ming Chen, Yupeng He, Liangjun Lu et al. · Antimicrobial Agents and Chemotherapy · 2007 · 55 citations · Full text

Hepatitis C, Plasma Hcv Rna, Viral Hepatitis +13

Inhibitors of HCV NS5B polymerase: synthesis and structure–activity relationships of N-1-heteroalkyl-4-hydroxyquinolon-3-yl-benzothiadiazines

John K. Pratt, Pamela Donner, Keith F. McDaniel et al. · Bioorganic & Medicinal Chemistry Letters · 2005 · 40 citations · Full text

Hcv Ns5b Polymerase, Biochemistry, Viral Polymerase Structure +10

Replication efficiency of chimeric replicon containing NS5A–5B genes derived from HCV-infected patient sera

Rakesh Tripathi, Preethi Krishnan, Yupeng He et al. · Antiviral Research · 2006 · 34 citations

Replication Efficiency, Viral Replication, Molecular Virology +11

Inhibitors of HCV NS5B polymerase: Synthesis and structure–activity relationships of N-alkyl-4-hydroxyquinolon-3-yl-benzothiadiazine sulfamides

A. Chris Krueger, Darold L. Madigan, Wen Jiang et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 34 citations · Full text

Hcv Ns5b Polymerase, N-alkyl-4-hydroxyquinolon-3-yl-benzothiadiazine Sulfamides, Viral Polymerase Structure +9