Impaired PI3K/Akt Activation-Mediated NF-κB Inactivation Under Elevated TNF-α Is More Vulnerable to Apoptosis in Vitiliginous Keratinocytes

Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN

Vuk Stambolic, Akira Suzuki, José Luís de la Pompa et al. · Cell · 1998 · 2.5K citations · Full text

Tumor Biology, Signal Transduction, Signaling Pathway +12

NF-κB activation by tumour necrosis factor requires the Akt serine–threonine kinase

Osman Nidai Özeş, Lindsey D. Mayo, Jason A. Gustin et al. · Nature · 1999 · 2.2K citations

Inflammation, Cytokine, Tumour Necrosis Factor +15

TRADD–TRAF2 and TRADD–FADD Interactions Define Two Distinct TNF Receptor 1 Signal Transduction Pathways

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Signal Transduction Pathways, Molecular Physiology, Signal Transduction +8

The lipid phosphatase activity of PTEN is critical for its tumor supressor function

Michael P. Myers, Ian Pass, Ian H. Batty et al. · Proceedings of the National Academy of Sciences · 1998 · 1.2K citations

Proteinlipid Interaction, Pathology, Lipid Phosphatase Activity +19

Dual Role of Phosphatidylinositol-3,4,5-trisphosphate in the Activation of Protein Kinase B

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