Inhibition of Lapatinib-Induced Kinome Reprogramming in ERBB2-Positive Breast Cancer by Targeting BET Family Bromodomains

BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

Jake Delmore, Ghayas C. Issa, Madeleine E. Lemieux et al. · Cell · 2011 · 2.8K citations · Full text

Medicine, Immunology, Therapeutic Efficacy +7

The Bromodomain Protein Brd4 Is a Positive Regulatory Component of P-TEFb and Stimulates RNA Polymerase II-Dependent Transcription

Moon Kyoo Jang, Kazuki Mochizuki, Meisheng Zhou et al. · Molecular Cell · 2005 · 1.3K citations · Full text

Transcriptional Regulation, Bromodomain Protein Brd4, Molecular Regulation +8

Recruitment of P-TEFb for Stimulation of Transcriptional Elongation by the Bromodomain Protein Brd4

Zhiyuan Yang, Jasper H. N. Yik, Ruichuan Chen et al. · Molecular Cell · 2005 · 1.1K citations · Full text

Transcriptional Regulation, Bromodomain Protein Brd4, Protein Expression +9

AKT Inhibition Relieves Feedback Suppression of Receptor Tyrosine Kinase Expression and Activity

Sarat Chandarlapaty, Ayana Sawai, Maurizio Scaltriti et al. · Cancer Cell · 2011 · 947 citations · Full text

Signal Transduction, Signaling Pathway, Functional Selectivity +8

Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma

Chong Sun, Liqin Wang, Sidong Huang et al. · Nature · 2014 · 896 citations · Full text

Photocarcinogenesis, Melanoma, Adaptive Resistance +3