Concepedia

Possible Protective Role for C-Reactive Protein in Atherogenesis

Sucharit Bhakdi, Michael Torzewski, Kerstin Paprotka, Steffen Schmitt, Hala Barsoom, Prapat Suriyaphol, Shan‐Rui Han, Karl J. Lackner, Matthias Husmann

Circulation · 2004 · 113 citations · 34 references

DOIFull text

Open access

Abstract

Binding of CRP to E-LDL is the first trigger for complement activation in the atherosclerotic lesion, but the terminal sequence is thereby spared. This putatively protective function of CRP is overrun at higher E-LDL concentrations, so that potentially harmful C5b-9 complexes are generated.

References

34

C-reactive protein: a critical update

Mark B. Pepys, Gideon M. Hirschfield · Journal of Clinical Investigation · 2003 · 3.3K citations · Full text

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C-Reactive Protein–Mediated Low Density Lipoprotein Uptake by Macrophages

Thomas P. Zwaka, Vinzenz Hombach, Jan Torzewski · Circulation · 2001 · 845 citations

C-Reactive Protein Binds to Apoptotic Cells, Protects the Cells from Assembly of the Terminal Complement Components, and Sustains an Antiinflammatory Innate Immune Response

Debra Gershov, SunJung Kim, Nathan Brot et al. · The Journal of Experimental Medicine · 2000 · 690 citations · Full text

C-Reactive Protein in the Arterial Intima

Michael Torzewski, Carsten Rist, Richard F. Mortensen et al. · Arteriosclerosis Thrombosis and Vascular Biology · 2000 · 578 citations

Interaction of C-reactive protein complexes with the complement system. I. Consumption of human complement associated with the reaction of C-reactive protein with pneumococcal C-polysaccharide and with the choline phosphatides, lecithin and sphingomyelin.

Melvin H. Kaplan, John E. Volanakis · PubMed · 1974 · 564 citations

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