Concepedia

A phase IB trial of 24-hour intravenous PX-12, a thioredoxin-1 inhibitor, in patients with advanced gastrointestinal cancers

Amanda F. Baker, K. N. Adab, Natarajan Raghunand, Helen Chow, Steven P. Stratton, Sean Squire, Michael Boice, Linda Pestano, David Kirkpatrick, Tomislav Dragovich

Investigational New Drugs · 2012 · 52 citations · 27 references

DOI

Concepts

References

27

AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1

Kiichi Hirota, Minoru Matsui, Satoshi Iwata et al. · Proceedings of the National Academy of Sciences · 1997 · 839 citations · Full text

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Oxidoreductive regulation of nuclear factor kappa B. Involvement of a cellular reducing catalyst thioredoxin

Takuma Hayashi, Yasushi Ueno, Takashi Okamoto · Journal of Biological Chemistry · 1993 · 489 citations · Full text

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The redox protein thioredoxin-1 (Trx-1) increases hypoxia-inducible factor 1alpha protein expression: Trx-1 overexpression results in increased vascular endothelial growth factor production and enhanced tumor angiogenesis.

Sarah J. Welsh, William Bellamy, Margaret M. Briehl et al. · PubMed · 2002 · 349 citations

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Thioredoxin reductase.

Debbie J. Mustacich, Garth Powis · PubMed · 2000 · 290 citations · Full text

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The thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1alpha and vascular endothelial growth factor formation.

Sarah J. Welsh, Ryan Williams, Anne Birmingham et al. · PubMed · 2003 · 252 citations

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