Margaret M. Briehl

The redox protein thioredoxin-1 (Trx-1) increases hypoxia-inducible factor 1alpha protein expression: Trx-1 overexpression results in increased vascular endothelial growth factor production and enhanced tumor angiogenesis.

Sarah J. Welsh, William Bellamy, Margaret M. Briehl et al. · PubMed · 2002 · 348 citations

Trx-1 Transfection, Immunology, Cell Death +21

Thioredoxin, a gene found overexpressed in human cancer, inhibits apoptosis in vitro and in vivo.

Amanda F. Baker, Claire M. Payne, Margaret M. Briehl et al. · PubMed · 1997 · 245 citations

Redox Protein Thioredoxin, Human Thioredoxin Cdna, Oncogenic Agent +15

Transfection with human thioredoxin increases cell proliferation and a dominant-negative mutant thioredoxin reverses the transformed phenotype of human breast cancer cells.

Alfred Gallegos, John R. Gasdaska, Charles W. Taylor et al. · PubMed · 1996 · 161 citations

Cancer Research, Human Thioredoxin Increases, Dominant-negative Mutant Thioredoxin +13

Isolation and Characterization of Transcripts Induced by Androgen Withdrawal and Apoptotic Cell Death in the Rat Ventral Prostate

Margaret M. Briehl, Roger L. Miesfeld · Molecular Endocrinology · 1991 · 120 citations · Full text

Catalase-overexpressing thymocytes are resistant to glucocorticoid-induced apoptosis and exhibit increased net tumor growth.

Margaret E. Tome, Amanda F. Baker, Garth Powis et al. · PubMed · 2001 · 109 citations

Catalase-overexpressing Cells, Lipid Peroxidation, Apoptosis +19