Estrogen Binding, Receptor mRNA, and Biologic Response in Osteoblast-Like Osteosarcoma Cells

Barry S. Komm, Christopher Terpening, D. Benz, +6

Science

Human Osteosarcoma CellsDissociation ConstantGynecologyBiologic ResponseOsteoporosis +16

Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase.

Garth Powis, Rosanne Bonjouklian, Margareta Berggren, +7

PubMed

Tyrosine KinaseCellular PharmacologyCellular PhysiologyMolecular PharmacologySignaling Pathway +15

Thioredoxin and thioredoxin reductase gene expression in human tumors and cell lines, and the effects of serum stimulation and hypoxia.

Margareta Berggren, Alfred Gallegos, John R. Gasdaska, +3

PubMed

Thioredoxin MrnaPathologyRedox BiologyTumor BiologyOxidative Stress +14

Increased expression of thioredoxin-1 in human colorectal cancer is associated with decreased patient survival

Jennifer Raffel, A. K. Bhattacharyya, Alfred Gallegos, +4

Journal of Laboratory and Clinical Medicine

OncologyMedicinePathologyColorectal CancerCell Death +7

3-(Hydroxymethyl)-Bearing Phosphatidylinositol Ether Lipid Analogues and Carbonate Surrogates Block PI3-K, Akt, and Cancer Cell Growth

Youhong Hu, Lixin Qiao, Shaomeng Wang, +6

Journal of Medicinal Chemistry

Thioredoxin, a putative oncogene product,is overexpressed in gastric carcinoma and associated with increased proliferation and increased cell survival

Thomas M. Grogan, Cecilia Fenoglio-Prieser, R Zeheb, +8

Human Pathology

Tumor BiologyIncreased ProliferationOncogenic AgentMedicineImmunology +5

Transfection with human thioredoxin increases cell proliferation and a dominant-negative mutant thioredoxin reverses the transformed phenotype of human breast cancer cells.

Alfred Gallegos, John R. Gasdaska, Charles W. Taylor, +6

PubMed

Cancer ResearchHuman Thioredoxin IncreasesDominant-negative Mutant ThioredoxinThioredoxin-transfected Mcf-7 CellsImmunology +11

Mechanisms of the regulation of thioredoxin reductase activity in cancer cells by the chemopreventive agent selenium.

Alfred Gallegos, Margareta Berggren, John R. Gasdaska, +1

PubMed

Chemoprevention StrategyCancer BiologyRedox BiologyTumor BiologyOxidative Stress +14

Thioredoxin Peroxidase-1 (peroxiredoxin-1) Is Increased in Thioredoxin-1 Transfected Cells and Results in Enhanced Protection against Apoptosis Caused by Hydrogen Peroxide but Not by Other Agents Including Dexamethasone, Etoposide, and Doxorubicin

Margareta Berggren, Bryan Husbeck, Betty K. Samulitis, +3

Archives of Biochemistry and Biophysics

InflammationAllergyRedox RegulatorMedicineApoptosis +11

In vitro and in vivo antitumor activity of the phosphatidylinositol-3-kinase inhibitor, wortmannin.

Richard M. Schultz, Ronald L. Merriman, Sherri L. Andis, +6

PubMed

Chemoprevention StrategyMitogenic SignalsImmunologyTumor BiologyMolecular Pharmacology +14